风湿消息
Mitochondrial aberrations in systemic lupus erythematosus pathogenesis: Insights and therapeutic implications
本文深入探讨了线粒体在系统性红斑狼疮(SLE)发病机制中的关键作用。研究详细阐述了线粒体异常与SLE发生和发展的紧密联系,包括线粒体DNA损伤、氧化应激、免疫代谢异常以及细胞死亡等机制。这些异常导致了SLE患者免疫系统的失调,从而引发自身抗原的攻击和炎症反应。文章还提出了针对线粒体相关途径的诊断和治疗策略,强调了靶向线粒体的治疗可能成为SLE管理的有效方法,为患者带来了新的希望。
How to cite: Li H, Zhou L, Zhou W, et al. Mitochondrial aberrations in systemic lupus erythematosus pathogenesis: Insights and therapeutic implications. Rheumatol & Autoimmun. 2024; 4: 69-80. doi:10.1002/rai2.12119
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Coronavirus disease 2019 vaccination in patients with rheumatic diseases: A bibliometric‐based analysis of trends
Xiufang Kong, Wei Wang
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Enhanced therapeutic effects of apoptotic cell-conditioned mesenchymal stem cells in lupus-prone MRL/lpr mice
凋亡细胞调理的间充质干细胞(AC-MSCs)通过COX2/PGE2途径表现出更强的T细胞抑制能力,但其对系统性红斑狼疮(SLE)的治疗效果尚不明确。本研究发现,AC-MSCs显著抑制浆细胞,该治疗组MRL/lpr小鼠的生存率显著提高,尿蛋白水平降低,肾脏免疫复合物沉积和自体抗体生成减少。此外,AC-MSCs抑制了炎症细胞因子的产生。结果显示,AC-MSCs在SLE小鼠中增强了治疗效果,凋亡细胞预处理可能是MSC移植治疗SLE的新策略。
How to cite: Zhang Z, Cui Y, Huang S, et al. Enhanced therapeutic effects of apoptotic cell-conditioned mesenchymal stem cells in lupus-prone MRL/lpr mice. Rheumatol & Autoimmun. 2024; 4: 90-98. doi:10.1002/rai2.12122
SLAMF8 as a potential biomarker for rheumatoid arthritis identified by comparing peripheral blood mononuclear cells, fibroblast‐like synoviocytes, and synovial tissue using bioinformatics analysis
Cheng Zhang, Huina Huang, Jie Zhang, Yifan Huang, Yuanhua Qin, Xia Li, Guan Wang
类风湿性关节炎(RA)是一种慢性自身免疫性炎症疾病,其发病机制尚不完全清楚。本研究通过生物信息学分析,构建蛋白-蛋白相互作用网络,并收集RA和OA患者滑膜组织,利用胶原诱导性关节炎小鼠模型进行验证。发现滑膜组织中差异表达基因(DEGs)最多。代谢和细胞因子信号通路对RA的发展至关重要。信号淋巴细胞活化分子家族(SLAMF)8在RA患者滑膜组织和胶原诱导的关节炎模型小鼠中显著升高。SLAMF8可能是RA的潜在治疗靶点。
How to cite: Zhang C, Huang H, Zhang J, et al. SLAMF8 as a potential biomarker for rheumatoid arthritis identified by comparing peripheral blood mononuclear cells, fibroblast-like synoviocytes, and synovial tissue using bioinformatics analysis. Rheumatol & Autoimmun. 2024; 4: 99-108. doi:10.1002/rai2.12117
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Assessing the causality of interferon‐γ and its receptor 1/2 with systemic lupus erythematosus risk using genetic data
Minjing Chang, Kaixin Yao, Jiawei Hao, Yinqi Long, Lulin Qiao, Yaru Zhang, Kexin Ma, Peifeng He
系统性红斑狼疮(SLE)中干扰素-γ(IFN-γ)信号通路被激活。本研究采用双向孟德尔随机化设计,评估IFN-γ、IFN-γ受体1(IFN-γR1)和IFN-γ受体2(IFN-γR2)与SLE的因果关联。结果显示,IFN-γ水平较高与SLE风险增加显著相关(OR=1.24, 95% CI: 1.03–1.47, p=0.018),而IFN-γR1和IFN-γR2与SLE风险无显著关联。这表明IFN-γ在SLE发病中起重要作用,抑制其水平可能成为SLE治疗的新策略。
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Integrated analysis of lncRNAs expression profiling in systemic lupus erythematosus
Fen Zhang, Guifang Zhao, Y ujie Bu, Xing Cen, Rong Zhao, Fengwu Chen, Shengxiao Zhang, Junwei Chen
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Combination therapy with methylprednisolone, rituximab, and tofacitinib in antimelanoma differentiation-associated 5 gene dermatomyositis with rapidly progressive interstitial lung disease
Mona Manghani, Weiyen Lim, Gin Tsen Chai, Xin Rong Lim, Choon Guan Chua
How to cite: Manghani M, Lim W, Chai GT, et al. Combination therapy with methylprednisolone, rituximab, and tofacitinib in antimelanoma differentiation-associated 5 gene dermatomyositis with rapidly progressive interstitial lung disease. Rheumatol & Autoimmun. 2024; 4: 122-125. doi:10.1002/rai2.12112
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Advancements in therapeutic paradigm: Harnessing IL-17A inhibitor secukinumab to ameliorate psoriasis vulgaris in the presence of resistant pericardial effusion
Qing Tan, Lifeng Xu, Ruoxi Wu, Zeying Lin, Wenhui Huang, Shuilian Yu
How to cite: Tan Q, Xu L, Wu R, Lin Z, Huang W, Yu S. Advancements in therapeutic paradigm: Harnessing IL-17A inhibitor secukinumab to ameliorate psoriasis vulgaris in the presence of resistant pericardial effusion. Rheumatol & Autoimmun. 2024; 4: 126-128. doi:10.1002/rai2.12101
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Systemic lupus erythematosus presenting with homonymous hemianopia
Aliasghar Ebrahimi, Mehrzad Hajialiloo, Sepideh Tahsini Tekantapeh, Pouya Vakilipour, Faegheh Ebrahimi Chaharom
本文报告了一名42 岁女性,她的视力模糊和右侧同名偏盲是 SLE 的最初表现,并且随着时间的推移而恶化。尽管以同侧偏盲形式出现狼疮脑炎作为首发表现的情况很罕见,但应在可疑的临床条件下考虑。
How to cite: Ebrahimi A, Hajialiloo M, Tekantapeh ST, Vakilipour P, Chaharom FE. Systemic lupus erythematosus presenting with homonymous hemianopia. Rheumatol & Autoimmun. 2024; 4: 129-130. doi:10.1002/rai2.12108
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Fibroblast diversity and clinical associations in systemic sclerosis
Ru Li
成纤维细胞是细胞外基质的主要来源,在纤维化组织的重塑中起着至关重要的作用。除其结构功能外,成纤维细胞还通过释放各种介质影响炎症过程和血管生成,可能在系统性硬化病(SSc)的炎症和血管病变方面发挥作用。最近发表在《J Invest Dermatol》杂志上的一项研究深入研究了成纤维细胞群的各种功能及其临床意义。作者对成纤维细胞群的异质性及其对SSc和其他纤维化疾病的影响提供了宝贵的见解,为更有针对性的治疗干预提供了途径。
How to cite: Li, R. (2024), Fibroblast diversity and clinical associations in systemic sclerosis. Rheumatology & Autoimmunity, 4: 131-131. https://doi.org/10.1002/rai2.12127
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Rheumatology & Autoimmunity是由中华医学会主办、中华医学杂志社与Wiley合作出版发行的全英文风湿病与免疫学专业期刊,发表风湿病与免疫学领域中临床诊治、转化及基础研究方面的新进展。涵盖风湿病学和免疫学的各个领域,旨在为国内外相关领域科学家与临床专家提供一个学术交流、信息传递的平台,同时提升我国风湿病与免疫学在国际学术界的影响力和竞争力。
期刊发表范围
涵盖风湿病学和临床免疫学的各个领域,包括各种风湿病、自身免疫病以及免疫学基础及转化医学研究。
感兴趣的主题
各种风湿病和自身免疫病的基础和临床研究,包括但不限于以下疾病:
• Rheumatoid Arthritis
类风湿关节炎
• Systemic Lupus Erythematosus
系统性红斑狼疮
• Sjogren Syndrome
干燥综合征
• Spondyloarthritis
脊柱关节炎
• Gout
痛风
• Osteoarthritis
骨关节炎
• Psoriatic Arthritis
银屑病关节炎
• Inflammatory Myopathy
炎性肌病
• Systematic Sclerosis
系统性硬化症
• Systemic Vasculitis
系统性血管炎