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  • 科室介绍

  • 图文组件
  • 图文组件

Overview
Department of Rheumatology and Immunology, Peking University People's Hospital, the Center of Clinical Immunology, Peking University, is one of the earliest and largest rheumatology centers in China. As a top National Key Center specialized in Rheumatology, the center has been titled as a National Center of Excellence in Rheumatology (certified in 2013), a National Key Laboratory in Clinical Immunology of the Ministry of Education of China (certified in 2005), Innovation team of the Ministry of Education of China (certified in 2011), Beijing Key Laboratory (certified in 2012), and the only International Cooperation Base in Rheumatic Diseases in Beijing (certified in 2015).

 

There are over 90 clinical and research faculties in this center, including 21 Professors and Associate Professors, 10 Attending physicians and residents, 24 nurses, 13 laboratory staff and nearly 30 PhD, Master and Post-doctoral researchers. Among them, there are 12 PhD supervisors, cosupervisors or postgraduate supervisors. 21 persons have studied abroad, 23 have published papers in English in international journals, 20 have been the project leaders of one or more national/Beijing Science and Technology Projects, 5 have been the leaders of national key or major projects.

 

The academic participations of the staff include Past-President of International Leagues Associations of Rheumatology (ILAR), Past-President of Asia Pacific League of Associations for Rheumatology (APLAR), Past-President of Chinese Rheumatology Association, President of Clinical Immunology Association of China, member of WHO-ICC, member of Chinese Rheumatology Association, member of Chinese Rheumatology Association, etc. The staff also serve as Associate Editor of Clinical Rheumatology and Int J Rheumatic Diseases, Chief Editor of Chinese Journal of Rheumatology, Journal of Clinical Immunology and Rheumatology, editorial board member of Nature Reviews Rheumatology, Rheumatology, Current Opinion in Rheumatology, Ann Rheum Dis, Clin Exp Rheumatology, Chinese Journal of Internal Medicine and National Medical Journal of China, reviewers of Lupus, J Rheumatology and over 10 other domestic and international journals.

 

A number of academic honors have been achieved, including "973" Chief Scientist, CMB Distinguished Professor, Winners of National Outstanding Youth Fund, Yang Wu Prize winner, the Ministry of Education Cross-Century Talents, China Medical Science and Technology Prize, China Medical Science and Technology Award, University Scientific Research and Technological Progress Award, Beijing Science Nova, etc.

The center has published over 500 decent papers as first or corresponding authors in Nature Medicine, Cell Host Microbe, Immunity, Annals of Internal Medicine, Annals of the Rheumatic Diseases, Arthritis Rheum, Autoimmunity, etc, among which over 120 are SCI papers. The center edited, translated or participated in the editing of over 30 books in rheumatology including Rheumatology, Kelley's Textbook of Rheumatology, Sjögren’s syndrome, etc.

 

The center focuses on rheumatic diseases such as rheumatoid arthritis, systemic lupus erythematosus and Sjögren’s syndrome, and has researched and developed more than 20 new specific markers and immune techniques in diagnosis, such as antibodies to the citrullinated HPVP, antibodies to citrullinated fibrinogen peptide, anti-mDNA, anti-nucleosome, anti- M3 receptor and anti-α-fodrin antibodies. Meanwhile, over 10 novel immune-based therapies have been used such as T cell vaccination for SLE.

 

Publications
1. Jing He, Xia Zhang, Yunbo Wei, Xiaolin Sun, Yaping Chen, Yuebo Jin, Xin Hu, RulinJia, Chuanhui Xu, Zhaohua Hou, Lei Zhu, Jinhong Feng, Yuan An, Yuan Jia, Chun Li, Xu Liu, Hua Ye, Limin Ren,Ru Li, Haihong Yao, Yuhui Li, Shi Chen, Xuewu Zhang, Yin Su, Jianping Guo, Nan Shen, Eric F. Morand, Di Yu and Zhanguo Li. Low-dose interleukin-2 treatment modulates CD4+ T cell subsets selectively in patients with systemic lupus erythematosus. Nature Medicine. 2016 (published online 8 August 2016) (IF 30.357)
2. Liu Y, Mu R, Gao YP, Dong J, Zhu L, Ma Y, Li YH, Zhang HQ, Han D, Zhang Y, McInnes IB, Zhang J, Shen B, Yang G, Li ZG.A Cytomegalovirus Peptide-Specific Antibody Alters Natural Killer Cell Homeostasis and Is Shared in Several Autoimmune Diseases. Cell Host Microbe. 2016 Mar 9;19(3):400-8.(IF 12.552)
3. He J, Tsai LM, Leong YA, Hu X, Ma CS, Chevalier N, Sun X, Vandenberg K, Rockman S, Ding Y, Zhu L, Wei W, Wang C, Karnowski A, Belz GT, Ghali JR, Cook MC, Riminton DS, Veillette A, Schwartzberg PL, Mackay F, Brink R, Tangye SG, Vinuesa CG, Mackay CR, Li Z, Yu D. Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺CD4⁺T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. Immunity. 2013; 39(4):770-81. (IF 24.082)
4. J Kremer, Zhan-Guo Li, et al. Tofacitinib in combination with nonbiologic disease-modifying antirheumatic drugs in patients with active rheumatoid arthritis: a randomized trial. Ann Intern Med. 2013; 159(4):253-261. (IF 16.44)
5. Hu F, Mu R, Zhu J, Shi L, Li Y, Liu X, Shao W, Li G, Li M, Su Y, Cohen PL, Qiu X, Li Z. Hypoxia and hypoxia-inducible factor-1α provoke toll-like receptor signalling-induced inflammation in rheumatoid arthritis. Ann Rheum Dis. 2014 May;73(5):928-36. (IF 12.384)
6. Wang T, Sun X, Zhao J, Zhang J, Zhu H, Li C, Gao N, Jia Y, Xu D, Huang FP, Li N, Lu L, Li ZG. Regulatory t cells in rheumatoid arthritis showed increased plasticity toward th17 but retained suppressive function in peripheral blood. Ann Rheum Dis. 2015;74 (6):1293-1301. (IF 12.384)
7. Du Y, Su Y, He J, Yang Y, Shi Y, Cui Y, Luo C, Wu X, Liu X, Hu F, Ma X, Zheng L, Zhang J, Zuo X, Sheng Y, Wu L, Zhang X, Guo J, Li Z1. Ann Rheum Dis. Impact of the leucocyte immunoglobulin-like receptor A3 (LILRA3) on susceptibility and subphenotypes of systemic lupus erythematosus and Sjögren's syndrome. 2014 Jun 6. doi: 10.1136/annrheumdis-2013-204441. (IF 10.377)
8. Guo, C., F. Hu, H. Yi, Feng Z, Li C, Shi L, Li Y, Liu H, Yu X, Wang H, Li J, Li Z, Wang XY. Myeloid-derived suppressor cells have a proinflammatory role in the pathogenesis of autoimmune arthritis. Ann Rheum Dis 2014 [Epub ahead of print]. (IF 10.377)
9. Li ZG. A new look at rheumatology in china--opportunities and challenges. Nature Reviews Rheumatology. 2015;11(5):313-317. (IF 9.845)
10. Du Y, Cui Y, Liu X, Hu F, Yang Y, Wu X, Liu X, Ma X, Zuo X, Sheng Y, Liu X, Xu J, Zhu P, Sun L, Hong N, Zhang X, Guo J, Li Z. Contribution of functional LILRA3, but not nonfunctional LILRA3, to sex bias in susceptibility and severity of anticitrullinated protein antibody-positive rheumatoid arthritis. Arthritis Rheumatol. 2014 Apr;66(4):822-30. (IF 7.764)
11. Hou Y, Lin H, Zhu L, Liu Z, Hu F, Shi J, Yang T, Shi X, Zhu M, Godley BF, Wang Q, Li Z, Zhao Y. Lipopolysaccharide increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA-1 expression. Arthritis Rheum. 2013 Nov;65(11):2835-46. (IF 7.764)
12. Zhu E, Wang X, Zheng B, Wang Q, Hao J, Chen S, Zhao Q, Zhao L, Wu Z, Jin Z. miR-20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting RORγt and STAT3. J Immunol. 2014, 15;192(12):5599-609. (IF 4.922)
13. Hu F, Liu H, Xu L, Li Y, Liu X, Shi L, Su Y, Qiu X, Zhang X, Yang Y, Zhang J, Li Z. Hypoxia-inducible factor-1alpha perpetuates synovial fibroblast interactions with t cells and b cells in rheumatoid arthritis. European journal of immunology. 2015. (Epub ahead of print)·
14. Sun J, Li R, Guo J, Jia Y, Sun X, Liu Y, Li Y, Huang F, Lu L, Li Z. A superior molecularly altered influenza virus haemagglutinin (HA) peptide HA308-317 inhibits CIA by inducing CD4+ regulatory T cell expansion. Arthritis Rheum. 2012; 64(7):2158-68. (IF 8.435)
15. Guo JP, Wu XY, Too CL, Ying FR, Lu XL, He J, Li R, Lu X, Murad S, Padyukov L, Li ZG. A replication study confirms the association of DCIR polymorphisms with ACPA negative RA in a large Asian cohort. PLoSOne.2012; 7(7): e41228. (IF 4.411)
16. Li R, Sun J, Ren LM, Wang HY, Liu WH, Zhang XW, Chen S, Mu R, He J, Zhao Y, Long L, Liu YY, Liu X, Lu XL, Li YH, Wang SY, Pan SS, Li C, Wang HY, Li ZG. Epidemiology of eight common rheumatic diseases in China: a large-scale cross-sectional survey in Beijing. Rheumatology (Oxford). 2012; 51(4): 721-29. (IF 4.435)
17. Li Z, Yang Y. Rheumatology in China: challenges and development. Rheumatology (Oxford). 2012;51(10):1733-4. (IF 4.435)
18. He J, Qiang L, Ding Y, Wei P, Li YN, Hua H, Li ZG. The role of muscarinic acetylcholine receptor type 3 polypeptide andtibody in the saliva of patients with primary Sjogren's syndrome. Clin Exp Rheumatol.2012;30(3):322-6.(IF 3.409)
19. Wu XY, Guo JP, Yin FR, Lu XL, Li R, He J, Liu X, Li ZG. Macrophage-inducible C-type lectin is associated with anti-cyclic citrullinated peptide antibodies-positive rheumatoid arthritis in men. Chin Med J (Engl). 2012; 125(17): 3115-19. (IF 1.016)
20. Ding Y, He J, Guo JP, Dai YJ, Li C, Feng M, Li R, Li ZG. Gender differences are associated with the clinical features of systemic lupus erythematosus. Chin Med J (Engl). 2012;125(14):2477-81. (IF 1.016)
21. Mu R, Sun XY, Lim LT, Xu CH, Dai CX, Su Y, Jia RL, Li ZG.Toll-like receptor 9 is correlated to disease activity in Chinese systemic lupus erythematosus population. Chin Med J (Engl). 2012 Aug;125(16):2873-7(IF 1.016)
22. He J, Ding Y, Feng M, Guo J, Sun X, Zhao J, Yu D, Li Z. Characteristics of Sjögren's syndrome in rheumatoid arthritis. Rheumatology (Oxford). 2013; 52(6):1084-9. (IF 4.435)
23. Hu F, Shi L, Mu R, Zhu J, Li Y, Ma X, Li C, Jia R, Yang D, Li Y, Li Z. Hypoxia-inducible factor-1α and interleukin 33 form a regulatory circuit to perpetuate the inflammation in rheumatoid arthritis. PLoS One. 2013; 8(8):e72650. (IF 3.534)
24. Liu X, Guo J, Jia Y, Zhao Y, Liu X, Cheng F, Li X, Zheng Y, Shi X, Li H, Huang C, Cheng Y, Lai B, Huang Y, Wang T, Ding B, Li Z. HLA-DRB1 shared epitope-dependent DR-DQ haplotypes are associated with both anti-CCP-positive and -negative rheumatoid arthritis in Chinese Han. PLoS One. 2013;8(8):e71373. (IF 3.534)
25. Sun X, Zhao J, Liu R, Jia R, Sun L, Li X, Li Z. Elevated serum and synovial fluid TNF-like ligand 1A (TL1A)is associated with autoantibody production in patients with rheumatoid arthritis. Scand J Rheumatol.2013; 42(2):97-101. (IF 2.607)
26. Tang S, Huang H, Hu F, Zhou W, Guo J, Jiang H, Mu R, Li Z. Increased IL-33 in synovial fluid and paired serum is associated with disease activity and autoantibodies in rheumatoid arthritis. ClinDevImmunol.2013; 2013: 985301. (IF 2.934)
27. Li M, Liu X, Sun X, Wang Z, Guo W, Hu F, Yao H, Cao X, Jin J, Wang PG, Shen J, Li Z. Therapeutic effects of NK-HDAC-1, a novel histone deacetylase inhibitor, on collagen-induced arthritis through the induction of apoptosis of fibroblast-like synoviocytes. Inflammation. 2013; 36(4):888-96. (IF 1.921)
28. Zhang X, Zhang F, Wu D, Bao C, Zhu P, Zhang X, Huang C, He D, Tao Y, Fang Y, Gu J, Wu H, Sun L, Yang X, Huang F, Xu H, Zhao D, Zhang M, Zheng Y, Li Z. Safety of infliximab therapy in rheumatoid arthritis patients with previous exposure to hepatitis B virus. Int J Rheum Dis. 2013; 16(4):408-12. (IF 1.771)
29. Mu R, Li C, Zhu JX, Zhang XY, Duan TJ, Feng M, Wang GC, Zhang FC, Li ZG. National survey of knowledge, attitude and practice of fibromyalgia among rheumatologists in China Int J Rheum Dis. 2013;16(3):258-63.(IF 1.771)
30. Li C, Mu R, Guo J, Wu X, Tu X, Liu X, Hu F, Guo S, Zhu J, Xu H, Li Z. Genetic variant in IL33 is associated with susceptibility to rheumatoid arthritis. Arthritis Res Ther. 2014, 29; 16(2):R105.
31. Du Y, Cui Y, Liu X, Hu F, Yang Y, Wu X, Liu X, Ma X, Zuo X, Sheng Y, Liu X, Xu J, Zhu P, Sun L, Hong N, Zhang X, Guo J, Li Z. Contribution of functional LILRA3, but not nonfunctional LILRA3, to sex bias in susceptibility and severity of anti-citrullinated protein antibody-positive rheumatoid arthritis. Arthritis Rheumatol. 2014; 66(4):822-30.
32. Hu F, Li Y, Zheng L, Shi L, Liu H, Zhang X, Zhu H, Tang S, Zhu L, Xu L, Yang Y, Li Z. Toll-Like Receptors Expressed by Synovial Fibroblasts perpetuate Th1 and Th17 Cell Responses in Rheumatoid Arthritis. PLoS One. 2014;17;9(6):e100266.
33. Ye H, Zhang XW, Mu R, Fang LK, Gu JR, Lin J, Du JF, Chen JW, Chen YJ, Wu LJ, Pang XF, Li ZG. Anti-TNF therapy in patients with HBV infection--analysis of 87 patients with inflammatory arthritis. Clin Rheumatol. 2014; 33(1):119-23.
34. Zhao J, Su Y, Li R, Ye H, Zou Q, Fang Y, Liu H, Li X, Guo J, Bi L, Gu F, Sun L, Mei Y, Zhang Z, Chen L, Zhu P, Li G, Zhang Z, LengX, Zhao Y, Jiang L, Zou H, Zhao Y, Liu Y, Li L, Wang H, Liu X, Li Z. Classification criteria of early rheumatoid arthritis and validation of its performance in a multi-centrecohort. Clin Exp Rheumatol.2014;32(5):667-73
35. Li C, Mu R, Lu XY, He J, Jia RL, Li ZG. Antilymphocyte antibodies in systemic lupus erythematosus: association with disease activity and lymphopenia. JImmunol Res. 2014;2014:672126.
36. Xu C, Wang X, Mu R, Yang L, Zhang Y, Han S, Li X, Wang Y, Wang G, Zhu P, Jin H, Sun L, Chen H, Cui L, Zhang Z, Li Z, Li J, Zhang F,Lin J, Liu X, Hu S, Yang X, Lai B, Li X, Wang X, Su Y, Li Z. Societal costs of rheumatoid arthritis in China: a hospital-based cross-sectional study. Arthritis Care Res (Hoboken).2014;66(4):523-31
37. Du Y, Liu X, Guo JP, Liu X, Li R, Zhao Y, Liu X, Li MH, Li ZG. Association between PADI4 gene polymorphisms and anti-cyclic citrullinated peptide antibody positive rheumatoid arthritis in a large Chinese Han cohort. Clin Exp Rheumatol. 2014 May-Jun;32(3):377-82.
38. Du Y, Su Y, He J, Yang Y, Shi Y, Cui Y, Luo C, Wu X, Liu X, Hu F, Ma X, Zheng L, Zhang J, Zuo X, Sheng Y, Wu L, Zhang X, Guo J, Li Z. Impact of the leucocyte immunoglobulin-like receptor A3 (LILRA3) on susceptibility and subphenotypes of systemic lupus erythematosus and Sjögren's syndrome. Ann Rheum Dis. 2014; 6.pii: annrheumdis-2013-204441.
39. Zhu H, Sun X, Zhu L, Hu F, Shi L, Li Z, Su Y. The expression and clinical significance of different forms of Mer Receptor Tyrosine Kinase in Systemic Lupus Erythematosus. J Immunol Res. 2014;2014:431896.
40. Zhu H, Sun X, Zhu L, Hu F, Shi L, Fan C, Li Z, Su Y. Different Expression Patterns and Clinical significanceof mAxl and sAxl in Systemic Lupus Erythematous. Lupus. 2014(23):624-634
41. Wang GY, Zhang SL, Wang XR, Feng M, Li C, An Y, Li XF, Wang LZ, Wang CH, Wang YF, Yang R, Yan HM, Wang GC, Lu X, Liu X, Zhu P, Chen LN, Jin HT, Liu JT, Guo HF, Chen HY, Xie JL, Wei P, Wang JX, Liu XY, Sun L, Cui LF, Shu R, Liu BL, Yu P, Zhang ZL, Li GT, Li ZB, Yang J, Li JF, Jia B, Zhang FX, Tao JM, Lin JY, Wei MQ, Liu XM, Ke D, Hu SX, Ye C, Han SL, Yang XY, Li H, Huang CB, Gao M, Lai B, Cheng YJ, Li XF, Song LJ, Yu XX, Wang AX, Wu LJ, Wang YH, He L, Sun WW, Gong L, Wang XY, Wang Y, Zhao Y, Li XX, Wang Y, Zhang Y, Su Y, Zhang CF, Mu R, Li ZG. Remission of rheumatoid arthritis and potential determinants: a national multi-center cross-sectional survey. Clin Rheumatol. 2014, Nov 22. DOI 10.1007/s10067-014-2828-3
42. Zhang XW, Li C, Ma XX, Zhao JX, An Y, Liu S, Li Y, Li ZG. Short interval lower-dose intravenous cyclophosphamide as induction and maintenance therapy for lupus nephritis: a prospective observational study. Clin Rheumatol. 2014;33(7):939-45.
43. Liu T, Li G, Mu R, Ye H, Li W, Li Z. Clinical and laboratory profiles of rhupus syndrome in a Chinese population: a single-centre study of 51 patients. Lupus. 2014;7;23(9):958-963.
44. Li Y, Sun X, Zhang X, Yang Y, Jia R, Liu X, Li R, Liu Y, Li Z. Establishment of a novel diagnostic model for Sjögren's syndrome by proteomic fingerprinting Clin Rheumatol. 2014 ;33(12):1745-50.
45. Hu F, Mu R, Zhu J, Shi L, Li Y, Liu X, Shao W, Li G, Li M, Su Y, Cohen PL, Qiu X, Li Z. Hypoxia and hypoxia-inducible factor-1α provoke toll-like receptor signalling-induced inflammation in rheumatoid arthritis. Ann Rheum Dis. 2014;73(5):928-36
46. Mu R, Bao CD, Chen ZW, Zheng Y, Wang GC, Zhao DB, Hu SX, Li YJ, Shao ZW, Zhang ZY, Xiao WG, Zhang W, Li ZG. Efficacy and safety of loxoprofen hydrogel patch versus loxoprofen tablet in patients with knee osteoarthritis: a randomized controlled non-inferiority trial. Clin Rheumatol Clin Rheumatol. 2014 Jun 14. [Epub ahead of print]
47. Li Y, Hu F, Dai Y, Li R, Ma X, Du Y, Feng M, Jia Y, Zhang C, Zhu L, Ascherman D, Li Z.Serum anti-lipocalin 2 IgG is a novel biomarker in diagnosis of systemic lupus erythematosus. Lupus. 2014.4;23(9):868-875.
48. Cheng Y, Chen Y, Sun X, Li Y, Huang C, Deng H, Li Z. Identification of potential serum biomarkers for rheumatoid arthritis by high resolution quantitative proteomic analysis. Inflammation. 2014;37(5):1459-67.
49. HU F,Zhu J,Mu R,Li YN,Shao WW, Philip L. Cohen, Qiu XY, Li ZG. Hypoxia and hypoxia-inducible factor-1α exacerbate Toll-like receptor signalling-engaged inflammatory response in rheumatoid arthritis synovial fibroblasts. IMMUNOLOGY. 2012, 137(Suppl. 1):580-580
50. HU F,Mu R,Zhu J,Shao WW,Shi LJ,Philip L. Cohen,Qiu XY,Li ZG. Hypoxia-Inducible Factor-1α:Trigger of Toll-Like Receptor Signalling-Engaged Inflammation in Rheumatoid Arthritis. ARTHRITIS RHEUM-US. 2014, 64(10):S460-S460
51. YUAN JIA, ERIC F. MORAND, WUQI SONG, QIANG CHENG, ALASTAIR STEWART4 AND YUAN H.YANG. Regulation of Lung Fibroblast Activation by Annexin A1.Journal of Cellular Physiology228:476–484, 2013.
52. HU F,Zhang L,Zheng J,Zhao L, Huang J,Shao WW,Liao QY,Ma T,Geng L,C. Cameron Yin,Qiu XY. Spontaneous Production of Immunoglobulin M in Human Epithelial Cancer Cells. PLOS ONE.2012, 7(12):1-14
53. Li ZG, Danis VA, Brooks PM. Effect of gonadal steroids on the production of IL-1 and IL-6 by blood mononuclear cells in vitro. Clin Exp Rheumatol. 1993, 11(2): 157-62.
54. Li ZG, Manolios N. Role of T-cell antigen receptors in rheumatic disease. Aust N Z J Med. 1993, 23(2):205-12.
55. Manolios N, Kemp O, Li ZG. The T cell antigen receptor alpha and beta chains interact via distinctregions with CD3 chains. Eur J Immunol. 1994, 24(1): 84-92.
56. Manolios N, Li ZG. The T cell antigen receptor beta chain interacts with the extracellular domain of CD3-gamma. Immunol Cell Biol. 1995, 73(6): 532-6.
57. Li ZG, Wu WP, Manolios N. Structural mutations in the constant region of the T-cell antigen receptor (TCR) beta chain and their effect on TCR alpha and beta chain interaction. Immunology. 1996, 88(4):524-30.
58. Li ZG, Kemp O, Longhurst T, Manolios N. Conformation of the T-cell antigen receptor-beta chain Cdomain contributes to V beta 3 epitope recognition by monoclonal antibody KJ25. Scand J Immunol.1996, 43(2): 140-5.
59. Li ZG, Wu WP and Manolios N. The interchain disulfide bond between the T-cell antigen receptor-αand chains is a prerequisite for T-cell activation. Cell Immunol. 1998, 190 (2): 101-11.
60. Li ZG, Han L, Jia RL, Li J. Impact of rheumatoid arthritis associated HLA-DRβ1 subtypes on proteinkinase A signaling. Chinese Medical Journal. 2003, 116 ( 5): 712-16.
61. Zhou Q, Cheng YJ, Li ZG. Inhibition of T-Cell activition with HLA-DR1/DR4 restricted non-T-Cell stimulating peptides. Human Immunol. 2003, 64: 857-65.
62. Ye H, Zhao MH, Gao Y, Guo XH, Wang HY. Anti-myeloperoxidase antibodies in sera from patients with propylthiouracil-induced vasculitis might recognize restricted epitopes on myeloperoxidase molecule. Clin Exp Immunol. 2004, 138(1): 179-82.
63. Ye H, Gao Y, Guo XH, Zhao MH. Titre and affinity of propylthiouracil-induced anti-myeloperoxidase antibodies are closely associated with the development of clinical vasculitis. Clin Exp Immunol. 2004,142(1): 116-9.
64. Cheng YJ, Zhou Q, Li ZG. The inhibitory effect of altered collagen II peptide on HLA-DRB1-restricted T cell activation. Scand J Immunol. 2005,61(3): 260-5.
65. Li X, Li R, Li Z. Altered influenza virus haemagglutinin peptides inhibit T cell responses to type II collagen in rheumatoid arthritis. . 2005,64(12: 1790-1.
66. Li ZG, Mu R, Dai ZP, Gao XM. T cell vaccination in systemic lupus erythematosus with autologous activated T cells. Lupus. 2005, 14: 884-9.
67. Li R, Li X, Li ZG. Altered collagen II peptides inhibited T-cell activation in rheumatoid arthritis. Clin Immunol. 2005, 118(2-3): 317-23.
68. Li X, Li R (coauthors), Li ZG. Inhibitory effects on HLA-DR1 specific T cell activation by influenza virus haemagglutinin-derived peptides. Tissue Antigens. 2005, 67(1): 45-52.
69. Li X, Li R (coauthors), Li ZG. Influenza virus haemagglutinin-derived peptides inhibit T cell activation induced by HLA-DR4/1 specific peptides in rheumatoid arthritis. Clin Exp Rheum. 2005, 24(2): 148-52.
70. He J, Chen QL, Li J, Li ZG. Antibodies to α-fodrin-derived peptide in Sjögren's Syndrome. Ann Rheum Dis. 2006 65(4): 549-50.
71. Su Y, Jia RL, Han L, Li ZG. Role of anti-nucleosome antibody in the diagnosis of systemic lupus erythematosus. Clin Immunol. 2007, 122(1): 115-20.
72. Yao ZQ, Li R, Li ZG. A triple altered collagen II peptide with consecutive substitutions of TCR contacting residues inhibits collagen-induced arthritis. Ann Rheum Dis. 2007, 66(3): 423-4.
73. Zhao Y, Tian X, Li Z. Prevalence and clinical significance of antibodies to citrullinated fibrinogen (ACF) in Chinese patients with rheumatoid arthritis. Clin Rheumatol. 2007, 26(9): 1505-12.
74. Ling S, Li Z, Borschukova O, Xiao L, Pumpens P, Holoshitz J. The rheumatoid arthritis shared epitope increases cellular susceptibility to oxidative stress by antagonizing an adenosine-mediated antioxidative pathway. Arthritis Res Ther. 2007, 9(1): R5.
75. Shi J, Sun X, Zhao Y, Zhao J, Li Z. Prevalence and significance of antibodies to citrullinated human papilloma virus-47 E2345-362 in rheumatoid arthritis. J Autoimmun. 2008,3 1(2): 131-5.
76. Sun XY, Shi J, Han L, Su Y, Li ZG. Anti-histones antibodies in systemic lupus erythematosus: prevalence and frequency in neuropsychiatric lupus. J Clin Lab Anal. 2008, 22(4): 271-7.
77. Zhao J, Zhao Y, He J, Jia R, Li Z. Prevalence and significance of anti-peptidylargininedeiminase 4antibodies in rheumatoid arthritis. J Rheumatol. 2008, 35(6): 969-74.
78. Zhao J, Li R, He J, Shi J, Long L, Li Z. Mucosal administration of an altered CII263-272 peptide inhibits collagen-induced arthritis by suppression of Th1/Th17 cells and expansion of regulatory T cells. Rheumatol Int. 2008, 29(1): 9-16.
79. Chen HY, Guo JL, Li ZG. Significance of anti-cell membrane-associated DNA (mDNA) antibodies in systemic lupus erythematosus. ClinRheumatol. 2008,27(2): 183-7.
80. Guo JP, Backdahl L, Marta M, Mathsson L, Ronnelid J, Lorentzen1 JC. Profound and paradoxical impact on arthritis and autoimmunity of the rat antigen-presenting lectin-like receptor complex. Arthritis Rheum. 2008, 58(5): 1343-53.
81. He, J, Zhao JX, Wang H, Li ZG. Mucosal administration of α-Fodrin inhibits Experimental Sjögren's syndrome autoimmunity. Arthritis Res Ther. 2008, 10: R44.
82. Dai H, Li Z, Zhang Y, Lv P, Gao XM. Elevated levels of serum IgA against Saccharomyces cerevisiaemannan in patients with rheumatoid arthritis. Cell MolImmunol. 2009: 361-6.
83. Zhao Y, Li J, Li XX, Li C, Li L, Li ZG. What can we learn from the presence of anti-cyclic citrullinated peptide antibodies in systemic lupus erythematosus? Joint Bone Spine. 2009, 76(5): 501-7.
84. Liu X, Jia R, Zhao J, Li Z. The role of anti-mutated citrullinatedvimentin antibodies in the diagnosis of early rheumatoid arthritis. J Rheumatol. 2009, 36(6): 1136-42.
85. Li R, Li X, Li ZG. Altered collagen II 263–272 peptide immunization induces inhibition of collagen induced arthritis through a shift toward Th2-type response. Tissue Antigens. 2009, 73(4): 341-7.
86. Guo JP, Verdrengh M, Tarkowski A, Lange S, Jennische E, Lorentzen JC, Harris R. The rat antigen presenting lectin-like receptor complex influences innate immunity and development of infectious diseases. Genes Immun. 2009, 10 (3): 227-36.
87. Luban S, Li ZG. Citrullinated peptide and its relevance to rheumatoid arthritis: an update. Int J Rheum Dis. 2010, 13(4): 284-7.
88. Su Y, Zhao Y, Liu X, Guo JP, Jiang Q, Liu XY, Zhang FC, Zheng Y, Li XX, Song H, Huang CB, Huang YH, Wang T, Pan SS, Li C, Liu X, Zhu L, Zhang CF, Li ZG. Variation in STAT4 is associated with systemic lupus erythematosus in Chinese Northern Han Population. Chin Med J (Engl). 2010, 123(22): 3173-77.
89. Zhao J, Liu X, Wang Z, Li Z. Significance of anti-CCP antibodies in modification of 1987 ACR classification criteria in diagnosis of rheumatoid arthritis. Clin Rheumatol. 2010, 29(1): 33-8.
90. Zhao J, Liu X, Wang Z, Liu R, Li Z. Is it necessary to combine detection of anticitrullinated protein antibodies in the diagnosis of rheumatoid arthritis? J Rheumatol. 2010, 37(12): 2462-5.
91. Long L, Liu YY, Wang SY, Zhao Y, Guo JP, Yu P, Li ZG. Dickkopf-1 as potential biomarker to evaluate bone erosion in systemic lupus erythematosus. J Clin Immunol. 2010: 30(5): 669-75.
92. Acetylcholine receptor is a novel marker in diagnosis of Sjogren's syndrome. Chinese Medical Journal. 2011.124(16): 2490-5.
93. Lu XL, Guo JP, Zhou XJ, Li R, Liu X, Zhao Y, Zhu BL, Liu XY, Xu JH, Zhu P, Wu XY, He J, Liu X, Zhang H, Li ZG. Deletion of LCE3C_LCE3B is associated with rheumatoid arthritis and systemic lupus erythematosus in the Chinese Han population. Ann Rheum Dis. 2011.70: 1648–51.
94. He J, Guo JP, Ding Y, Li YN, Pan SS, Liu YY, Li ZG. Diagnostic significance of measuring antibodies peptides to cyclic type 3 muscarinic acetylcholine receptor in primary Sjogren's syndrome. Rheumatology. 2011; 50: 879-84.
95. Sun J, Jia Y, Li R, Guo JP, Sun XL, Liu YY, Li YN, Yao HH, Liu X, Zhao J, Li ZG. Altered influenza virus haemagglutinin (HA)-derived peptide is potent therapy for CIA by inducing Th1 to Th2 shift. Cell Mol Immunol. 2011, 8(4): 348-58.
96. Gao H, Li C, Mu R, Guo YQ, Liu T, Chen S, Su Y, Li ZG. Subclinical hypothyroidism and its association with lupus nephritis: a case control study in a large cohort of Chinese systemic lupus erythematosus patients. Lupus. 2011, 20: 1035–41.
97. Long L, Li R, Li YZ, Hu CJ, Li ZG. Pattern-based diagnosis and screening of differentially expressed serum proteins for rheumatoid arthritis by proteomic fingerprinting. Rheumatol Int. 2011, 31(8): 1069-74.
98. Lu XL, Guo JP, Zhou XJ, Jia RL, Zhao Y, Zhang Q, Liu XY, Liu Y, Sun LY, Zhang H, Li ZG. Rs548234polymorphism at PRDM1-ATG5 region susceptible to rheumatoid arthritis (RA) in Caucasians is not associated. Chin Med J (Engl). 2011, 124(18): 2863-7.
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102. Mu R, Huang HQ, Li YH, Li C, Ye H, Li ZG. Elevated serum interleukin 33 is associated with autoantibody production in patients with rheumatoid arthritis. J Rheum. 2010, 37(10): 2007-11.
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112. Minghui Li, Xu Liu, Xiaolin Sun, Zhenhua Wang, Weikang Guo, Fanlei Hu, Haihong Yao, Xuefeng Cao, Jin Jin, Peng G. Wang, Jie Shen*, Zhanguo Li*,Therapeutic Effects of NK-HDAC-1, a Novel Histone Deacetylase Inhibitor, on Collagen-Induced Arthritis through the Induction of Apoptosis of Fibroblast-Like Synoviocytes. Inflammation. 2013 Apr 3. N/A.
113. Fanlei Hu, Rong Mu, Jiaxin Zhu, Lianjie Shi, Yingni Li, Xu Liu, Wenwei Shao, GuiyeLi, Minghui Li, Yin Su, Philip L. Cohen*, Xiaoyan Qiu*, Zhanguo Li*. Hypoxia and hypoxia-inducible factor-1α provoke toll-like receptor signalling-induced inflammation in rheumatoid arthritis. Ann Rheum Dis. 2013 May 3, N/A.

 

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