He J, Zhang X, Wei YB, Sun XL, Chen YP, Deng J, Jin YB, Gan YZ, Hu X, Jia RL, Xu CH, Hou ZH, Leong YA, Zhu L, Feng JH, An Y, Jia Y, Li C, Liu X, Ye H, Ren LM, Li R, Yao HH, Li YH, Chen S, Zhang XW, Su Y, Guo JP, Shen N, Morand EF, Yu D, Li ZG. Low-dose interleukin-2 treatment selectively modulates CD4(+) T cell subsets in patients with systemic lupus erythematosus. NAT MED 2016;22:991.
Chen XJ, Sun XL, Yang W, Yang B, Zhao XZ, Chen ST, He LL, Chen H, Yang CM, Xiao L, Chang Z, Guo JP, He J, Zhang FP, Zheng F, Hu ZB, Yang ZY, Lou JZ, Zheng WJ, Qi H, Xu CQ, Zhang H, Shan HY, Zhou XJ, Wang QW, Shi Y, Lai LH, Li ZG, Liu WL. An autoimmune disease variant of IgG1 modulates B cell activation and differentiation. SCIENCE 2018;362:700.
Liu Y, Mu R, Gao YP, Dong J, Zhu L, Ma YY, Li YH, Zhang HQ, Han D, Zhang Y, McInnes IB, Zhang JG, Shen BF, Yang G, Li ZG. A Cytomegalovirus Peptide-Specific Antibody Alters Natural Killer Cell Homeostasis and Is Shared in Several Autoimmune Diseases. Cell Host& Microbe 2016;19:400.
Fanlei Hu; Xiang Jiang; Chunqing Guo; Yingni Li; Shixian Chen; Wei Zhang; Yan Du; Ping Wang; Xu Liu; Limin Ren; Xiaoying Zhang; Jianping Guo; Hudan Pan; Yin Su; Huanfa Yi; Hua Ye; Daming Zuo; Juan Li; Yongfu Wang; Ru Li; Liang Liu; Zhanguo Li .Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scalemulticenter study. Nature Communications. 2020, 11(1): 1-14.
He J, Chu Y, Li J, Meng Q, Liu Y, Jin J, Wang Y, Wang J, Huang B, Shi L, Shi X, Tian J, Zhufeng Y, Feng R, Xiao W, Gan Y, Guo J, Shao C, Su Y, Hu F, Sun X, Yu J, Kang Y, Li Z. Intestinal butyrate-metabolizing species contribute to autoantibody production and bone erosion in rheumatoid arthritis. Science Advances. 2022 Feb 11;8(6):eabm1511.
Yinhua Zhu, Lu Wang, Jing Li, Yuan Zhao, Xuerong Yu, Ping Liu, Xiaobing Deng, Jingjing Liu, Fan Yang, Yini Zhang, Jiaojiao Yu, Luhua Lai, Chu Wang, Zhanguo Li, Lei Wang, Tuoping Luo. Photoaffinity labeling coupled with proteomics identify PDI-ADAM17 module is targeted by (-)-vinigrol to induce TNFR1 shedding and ameliorate rheumatoid arthritis in mice. Cell Chem Biol. 2023 Oct 23:S2451-9456(23)00339-2.
Li C, Huang J, Wu H, Li F, Zhao Y, Zhang Z, Li S, Wei H, Zhang M, Sun H, Yang J, Li Q, Li X, Qi W, Wei W, Li Y, Li Z, Wang Y, Zhang F, Wu H, Shuai Z, Wu Z, Li Y, Jia S, Jia Y, Xiao F, Mu R, Li Z. Management of Rheumatoid Arthritis With a Digital Health Application: A Multicenter, Pragmatic Randomized Clinical Trial. JAMA Network Open. 2023 Apr 3;6(4):e238343.
He J, Chen J, Miao M, Zhang R, Cheng G, Wang Y, Feng R, Huang B, Luan H, Jia Y, Jin Y, Zhang X, Shao M, Wang Y, Zhang X, Li J, Zhao X, Wang H, Liu T, Xiao X, Zhang X, Su Y, Mu R, Ye H, Li R, Liu X, Liu Y, Li C, Liu H, Hu F, Guo J, Liu W, Zhang WB, Jacob A, Ambrus JL Jr, Ding C, Yu D, Sun X, Li Z. Efficacy and Safety of Low-Dose Interleukin 2 for Primary Sjögren Syndrome: A Randomized Clinical Trial. JAMA Network Open. 2022 Nov 1;5(11):e2241451.
Sun X, Li R, Cai Y, Al-Herz A, Lahiri M, Choudhury MR, Hidayat R, Suryana BPP, Kaneko Y, Fujio K, Van Hung N, Pandya S, Pang LK, Katchamart W, Sigdel KR, Paudyal B, Narongroeknawin P, Chevaisrakul P, Sun F, Lu Y, Ho C, Yeap SS, Li Z; APLAR RA SIG group. Clinical remission of rheumatoid arthritis in a multicenter real-world study in Asia-Pacific region. The Lancet Regional Health - Western Pacific. 2021 Aug 12;15:100240.
Mu R, Li C, Li X, Ke Y, Zhao L, Chen L, Wu R, Wu Z, Zuo X, Xie Y, Chen J, Wei W, Liu Y, Li Z, Dai L, Sun L, Liu X, Li Z. Effectiveness and safety of iguratimod treatment in patients with active rheumatoid arthritis in Chinese: A nationwide, prospective real-world study. The Lancet Regional Health - Western Pacific. 2021 Mar 22;10:100128.
Yue Yang, Jingyang Li,Ju Liu,Lin Liu, Yongfu Wang, Jiankang Hu,Zhijun Li, Jieruo Gu,Xiao Zhang, Zhengyu Xiao, Junjie Zheng,Lin Liu, Zhanguo Li,and James Cheng-Chung Wei. Safety and efficacy of peficitinib in Asian patients with rheumatoid arthritis who had an inadequate response or intolerance to methotrexate: results of a multicenter, randomized, double-blind, placebo-controlled phase 3 study. The Lancet Regional Health - Western Pacific 2023; 100925.
He, J., X.L. Sun, and Z.G. Li, Low-dose IL-2 for patients with systemic lupus erythematosus. LANCET RHEUMATOLOGY, 2019. 1(4): p. E203-E203
Zhang X, Miao M, Zhang R, Liu X, Zhao X, Shao M, Liu T, Jin Y, Chen J, Liu H, Zhang X, Li Y, Zhou Y, Yang Y, Li R, Yao H, Liu Y, Li C, Li Y, Ren L, Su Y, Sun X, He J, Li Z. Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase 2 trial. Signal Transduct Target Ther. 2022 Mar 7;7(1):67.
Li J, Jin J, Li S, Zhong Y, Jin Y, Zhang X, Xia B, Zhu Y, Guo R, Sun X, Guo J, Hu F, Xiao W, Huang F, Ye H, Li R, Zhou Y, Xiang X, Yao H, Yan Q, Su L, Wu L, Luo T, Liu Y, Guo X, Qin J, Qi H, He J, Wang J, Li Z. Tonsillar Microbiome-Derived Lantibiotics Induce Structural Changes of IL-6 and IL-21 Receptors and Modulate Host Immunity. ADVANCED SCIENCE (WEINH). 2022 Oct;9(30):e2202706.
Xia M, Liu J, Liu S, Chen K, Lin H, Jiang M, Xu X, Xue Y, Liu W, Gu Y, Zhang X, Li Z, Yi L, Qian Y, Zhou C, Li R, Zhang X, Li Z, Cao X. Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity. NATURE COMMUNICATIONS. 2017 Jun 9;8:15818.
Wang T, Sun XL, Zhao J, Zhang J, Zhu HQ, Li C, Gao N, Jia Y, Xu DK, Huang FP, Li NL, Lu LW, Li ZG. Regulatory T cells in rheumatoid arthritis showed increased plasticity toward Th17 but retained suppressive function in peripheral blood. ANN RHEUM DIS 2015;74:1293.
Li ZG. A new look at rheumatology in China-opportunities and challenges. NAT REV RHEUMATOL 2015;11:313.
Guo CQ, Hu FL, Yi HF, Feng ZT, Li CZ, Shi LJ, Li YN, Liu HJ, Yu XF, Wang HX, Li J, Li ZG, Wang XY. Myeloid-derived suppressor cells have a proinflammatory role in the pathogenesis of autoimmune arthritis. ANN RHEUM DIS 2016;75:278.
Du Y, Su Y, He J, Yang Y, Shi YM, Cui Y, Luo CN, Wu XY, Liu X, Hu FL, Ma XX, Zheng L, Zhang J, Zuo XB, Sheng YJ, Wu LJ, Zhang XJ, Guo JP, Li ZG. Impact of the leucocyte immunoglobulin-like receptor A3 (LILRA3) on susceptibility and subphenotypes of systemic lupus erythematosus and Sjogren's syndrome. ANN RHEUM DIS 2015;74:2070.
Hu FL, Mu R, Zhu JX, Shao WW, Shi LJ, Cohen PL, Qiu XY, Li ZG. Hypoxia-Inducible Factor-1 alpha: Trigger of Toll-Like Receptor Signalling-Engaged Inflammation in Rheumatoid Arthritis. ANN RHEUM DIS 2014;73:928-936.
Zhou P, Chen J, He J, Zheng T, Yunis J, Makota V, Alexandre YO, Gong F, Zhang X, Xie W, Li Y, Shao M, Zhu Y, Sinclair JE, Miao M, Chen Y, Short KR, Mueller SN, Sun X, Yu D, Li Z. Low-dose IL-2 therapy invigorates CD8+ T cells for viral control in systemic lupus erythematosus. PLoS Pathog. 2021 Oct 7;17(10):e1009858.
Yu D, Walker LSK, Liu Z, Linterman MA, Li Z. Targeting TFH cells in human diseases and vaccination: rationale and practice. Nat Immunol. 2022 Aug;23(8):1157-1168.
Li, ZG; He, J; Yu, D. The rise of IL-2 therapy a picture beyond T-reg cells. NATURE REVIEWS RHEUMATOLOGY. 2017; 13(6): 386.
He J, Zhang R, Shao M, Zhao X, Miao M, Chen J, Liu J, Zhang X, Zhang X, Jin Y, Wang Y, Zhang S, Zhu L, Jacob A, Jia R, You X, Li X, Li C, Zhou Y, Yang Y, Ye H, Liu Y, Su Y, Shen N, Alexander J, Guo J, Ambrus J, Lin X, Yu D, Sun X, Li Z. Efficacy and safety of low-dose IL-2 in the treatment of systemic lupus erythematosus: a randomised, double-blind, placebo-controlled trial. ANN RHEUM DIS. 2020 Jan;79(1):141-149.
Guo J, Zhang T, Cao H, Li X, Liang H, Liu M, Zou Y, Zhang Y, Wang Y, Sun X, Hu F, Du Y, Mo X, Liu X, Yang Y, Yang H, Wu X, Zhang X, Jia H, Jiang H, Hou Y, Liu X, Su Y, Zhang M, Yang H, Wang J, Sun L, Liu L, Padyukov L, Lai L, Yamamoto K, Zhang X, Klareskog L, Xu X, Li Z. Sequencing of the MHC region defines HLA-DQA1 as the major genetic risk for seropositive rheumatoid arthritis in Han Chinese population. ANN RHEUM DIS.2019 Jun;78(6):773-780.
Bonfá E, Gossec L, Isenberg DA, Li Z, Raychaudhuri S. How COVID-19 is changing rheumatology clinical practice. NAT REV RHEUMATOL. 2021 Jan;17(1):11-15.
Smolen JS, Landewé RBM, Bergstra SA, Kerschbaumer A, Sepriano A, Aletaha D, Caporali R, Edwards CJ, Hyrich KL, Pope JE, de Souza S, Stamm TA, Takeuchi T, Verschueren P, Winthrop KL, Balsa A, Bathon JM, Buch MH, Burmester GR, Buttgereit F, Cardiel MH, Chatzidionysiou K, Codreanu C, Cutolo M, den Broeder AA, El Aoufy K, Finckh A, Fonseca JE, Gottenberg JE, Haavardsholm EA, Iagnocco A, Lauper K, Li Z, McInnes IB, Mysler EF, Nash P, Poor G, Ristic GG, Rivellese F, Rubbert-Roth A, Schulze-Koops H, Stoilov N, Strangfeld A, van der Helm-van Mil A, van Duuren E, Vliet Vlieland TPM, Westhovens R, van der Heijde D. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update. ANN RHEUM DIS. 2023 Jan;82(1):3-18.
Wang, T; Sun, XL; Zhao, J; Zhang, J; Zhu, HQ; Li, C; Gao, N; Jia, Y; Xu, DK; Huang, FP; Li, NL; Lu, LW; Li, ZG. Regulatory T cells in rheumatoid arthritis showed increased plasticity toward Th17 but retained suppressive function in peripheral blood. ANN RHEUM DIS. 2015; 74(6): 1293-1301.
Hu W, Zhang Y, Sun X, Zhang T, Xu L, Xie H, Li Z, Liu W, Lou J, Chen W. FcγRIIB-I232T polymorphic change allosterically suppresses ligand binding. Elife. 2019 Jul 25;8:e46689.
Takeuchi, T; Genovese, MC; Haraoui, B; Li, ZG; Xie, L; Klar, R; Pinto-Correia, A; Otawa, S; Lopez-Romero, P; de la Torre, I; Macias, W; Rooney, TP; Smolen, JS.Dose reduction of baricitinib in patients with rheumatoid arthritis achieving sustained disease control: results of a prospective study. ANN RHEUM DIS. 2019; 78(2):171-178.
Xu, LL; Xia, MD; Guo, J; Sun, XL; Li, H; Xu, CG; Gu, XM; Zhang, HW; Yi, JY; Fang, Y; Xie, HY; Wang, J; Shen, ZX; Xue, BX; Sun, YJ; Meckel, T; Chen, YH; Hu, ZB; Li, ZG; Xu, CQ; Gong, HP; Liu, WL. Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism Fc gamma RIIB-T232. JOURNAL OF EXPERIMENTAL MEDICINE. 2016; 213(12): 2707-2727.
Zhang Y, Li Y, Zhang J, Chen X, Zhang R, Sun G, Jiang B, Fan K, Li Z, Yan X. Nanocage-Based Capture-Detection System for the Clinical Diagnosis of Autoimmune Disease. SMALL. 2021 Jun;17(25):e2101655.
Hu S, Liu X, Li T, Li Z, Hu F. LAG3 (CD223) and autoimmunity: Emerging evidence. J Autoimmun. 2020 Aug;112:102504.