风湿消息
RAI | 系统性红斑狼疮前沿进展-2023/2024（摘要精选）
Mitochondrial aberrations in systemic lupus erythematosus pathogenesis: Insights and therapeutic implications (Review)
本文深入探讨了线粒体在系统性红斑狼疮（SLE）发病机制中的关键作用。研究详细阐述了线粒体异常与SLE发生和发展的紧密联系，包括线粒体DNA损伤、氧化应激、免疫代谢异常以及细胞死亡等机制。这些异常导致了SLE患者免疫系统的失调，从而引发自身抗原的攻击和炎症反应。文章还提出了针对线粒体相关途径的诊断和治疗策略，强调了靶向线粒体的治疗可能成为SLE管理的有效方法，为患者带来了新的希望。
How to cite: Li H, Zhou L, Zhou W, et al. Mitochondrial aberrations in systemic lupus erythematosus pathogenesis: Insights and therapeutic implications. Rheumatol & Autoimmun. 2024; 4: 69-80. doi:10.1002/rai2.12119
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Unveiling the nexus: Decoding interactions between regulated cell death and systemic lupus erythematosus pathogenesis for innovative therapeutic avenues (Review)
Qing Tan, Wenhui Huang, Yu Zheng, Mingyan Li, Yi Tao, Shuilian Yu
本文探讨了调节性细胞死亡在系统性红斑狼疮(SLE)患者发病机制中的复杂相互作用，包括细胞凋亡、坏死性凋亡、焦亡、NET介导的细胞死亡、自噬和铁死亡。这些途径释放自身抗原和危险信号，导致细胞膜破坏，产生细胞内免疫刺激成分，影响许多免疫细胞亚群的发育、分化、功能和代谢，并引发强烈的炎症免疫反应。揭示两者之间的联系为扩大狼疮治疗的版图带来了希望。
How to cite:Tan Q, Huang W, Zheng Y, Li M, Tao Y, Yu S. Unveiling the nexus: decoding interactions between regulated cell death and systemic lupus erythematosus pathogenesis for innovative therapeutic avenues. Rheumatol & Autoimmun.2024; 4: 1-10. doi:10.1002/rai2.12104
Podocyte injury and death: New insights into lupus nephritis pathogenesis and therapy (Review)
Xiaolei Shi, Zhipeng Wang, Ruihan Tang, Wei Chen
How to cite: Shi
Mesenchymal stem cell transplantation as a potential therapy for refractory lupus nephritis: A systematic review (Review)
Faisal Parlindungan, Johanda Damanik, Abirianty P. Araminta, Ariel V. Soetedjo, Rudy Hidayat, Suryo A. Kusumo Wibowo, Anna Arianne, Sumariyono Sumariyono
How to cite: Parlindungan, F, Damanik, J, Araminta, AP, et al. Mesenchymal stem cells transplantation as a potential therapy for refractory lupus nephritis: a systematic review. Rheumatol & Autoimmun. 2023; 3: 140-148. doi:10.1002/rai2.12082
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Dual autoimmune diseases: Rheumatoid arthritis with systemic lupus erythematosus and Type 1 diabetes mellitus with multiple sclerosis (Review)
CircEPSTI1 in peripheral blood as a novel potential biomarker for childhood-onset systemic lupus erythematosus (Original Article)
本文评估了circEPSTI1 在儿童系统性红斑狼疮的诊断和疾病活动度监测中的作用，circEPSTI1在红斑狼疮患儿中的表达水平高于健康儿童、幼年皮肌炎患儿和幼年特发性关节炎患儿。circEPSTI1在患有红斑狼疮和肾脏受累的儿童中的表达水平高于无肾脏受累的儿童。发现circEPSTI1是儿童系统性红斑狼疮潜在的生物标志物。
How to cite: Wang X, Li S, Deng J, et al. CircEPSTI1 in peripheral blood as a novel potential biomarker for childhood-onset systemic lupus erythematosus. Rheumatol & Autoimmun. 2024; 4: 20-26. doi:10.1002/rai2.12096
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Assessing the causality of interferon‐γ and its receptor 1/2 with systemic lupus erythematosus risk using genetic data (Original Article)
Minjing Chang, Kaixin Yao, Jiawei Hao, Yinqi Long, Lulin Qiao, Yaru Zhang, Kexin Ma, Peifeng He
系统性红斑狼疮（SLE）中干扰素-γ（IFN-γ）信号通路被激活。本研究采用双向孟德尔随机化设计，评估IFN-γ、IFN-γ受体1（IFN-γR1）和IFN-γ受体2（IFN-γR2）与SLE的因果关联。结果显示，IFN-γ水平较高与SLE风险增加显著相关（OR=1.24, 95% CI: 1.03–1.47, p=0.018），而IFN-γR1和IFN-γR2与SLE风险无显著关联。这表明IFN-γ在SLE发病中起重要作用，抑制其水平可能成为SLE治疗的新策略。
Enhanced therapeutic effects of apoptotic cell-conditioned mesenchymal stem cells in lupus-prone MRL/lpr mice (Original Article)
凋亡细胞调理的间充质干细胞（AC-MSCs）通过COX2/PGE2途径表现出更强的T细胞抑制能力，但其对系统性红斑狼疮（SLE）的治疗效果尚不明确。本研究发现，AC-MSCs显著抑制浆细胞，该治疗组MRL/lpr小鼠的生存率显著提高，尿蛋白水平降低，肾脏免疫复合物沉积和自体抗体生成减少。此外，AC-MSCs抑制了炎症细胞因子的产生。结果显示，AC-MSCs在SLE小鼠中增强了治疗效果，凋亡细胞预处理可能是MSC移植治疗SLE的新策略。
How to cite: Zhang Z, Cui Y, Huang S, et al. Enhanced therapeutic effects of apoptotic cell-conditioned mesenchymal stem cells in lupus-prone MRL/lpr mice. Rheumatol & Autoimmun. 2024; 4: 90-98. doi:10.1002/rai2.12122
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Yi Tong V. Aw, Phillip J. Whiley, Ayla May Lorenzo, Tom Lea-Henry, Somasundhari Shanmuganandam, Maurice Stanley, Sonia N. Babu, Vicki Athanasopoulos, Jean Cappello, Julia I. Ellyard, Matthew Cook, Carola Vinuesa, Giles Walters, David A. Fulcher, Simon H. Jiang
流式细胞术分析用于检查伴或不伴肾炎的系统红斑狼疮患者与健康献血者的外周血淋巴细胞的细胞群差异。与健康献血者相比，系统红斑狼疮患者的边缘区B细胞，记忆B细胞和外周血滤泡辅助性T细胞减少。与未患狼疮性肾炎的系统红斑狼疮患者和健康献血者相比，狼疮性肾炎患者的辅助性T细胞2（Th2）和调节性T细胞增加。
Qi Cheng, Xin Chen, Jieying Xu, Mo Chen, Peiyu Zhang, Huaxiang Wu, Yan Du
研究人员通过分析79名系统性红斑狼疮（SLE）患者，14名类风湿性关节炎（RA）患者和23名健康对照，确定XIST基因在外周血单个核细胞(PBMC)细胞和CD4+ T细胞中的表达，并对XIST基因的表达和SLE患者的临床特征进行了相关性分析，以确定XIST基因的功能。采用生物信息学方法，包括对靶向miRNA和基因的预测、ceRNA网络的构建、功能和通路富集分析等，探讨了XIST的功能和调控机制。结果表明，XIST基因在调控SLE患者的CD4+ T细胞miR-17-92簇和CEACAM8表达起作用。
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更多好文
Systemic lupus erythematosus presenting with homonymous hemianopia
A painless growing abdominal mass in a patient with systemic lupus erythematosus
Integrated analysis of lncRNAs expression profiling in systemic lupus erythematosus
HLA-DQ and -DR alleles in patients with SLE: A tertiary hospital-based case–control study in Bangladesh
Belimumab shows promise in neuropsychiatric lupus: Another challenge to find the offender
Identification and functional analysis of shared gene signatures between systemic lupus erythematosus and Sjögren's syndrome
Single nucleotide polymorphism (SNP) in genes of lupus: A Philippine study (SIGLA-PH)
Association between HLA-B and HLA-DRB1 polymorphisms and systemic lupus erythematosus in Han population in China
Effect of human umbilical cord mesenchymal stem cells on ovarian function in lupus mice
Understand SLE heterogeneity in the era of omics, big data, and artificial intelligence
Noncanonical autophagy in systemic lupus erythematosus
MSCs relieve SLE by modulation of Th17 cells through MMPs–CCL2–CCR2–IL-17 pathway
期刊发表范围
涵盖风湿病学和临床免疫学的各个领域，包括各种风湿病、自身免疫病以及免疫学基础及转化医学研究。
感兴趣的主题
各种风湿病和自身免疫病的基础和临床研究，包括但不限于以下疾病：
• Rheumatoid Arthritis
类风湿关节炎
• Systemic Lupus Erythematosus
系统性红斑狼疮
• Sjogren Syndrome
干燥综合征
• Spondyloarthritis
脊柱关节炎
• Gout
痛风
• Osteoarthritis
骨关节炎
• Psoriatic Arthritis
银屑病关节炎
• Inflammatory Myopathy
炎性肌病
• Systematic Sclerosis
系统性硬化症
• Systemic Vasculitis
系统性血管炎
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