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  风湿病知识

栗占国

 

栗占国,主任医师,教授,博士生导师,北京大学人民医院临床免疫中心/风湿免疫科主任,风湿免疫研究所所长,北京大学医学部风湿免疫学系主任,北京大学临床免疫中心主任,国家杰出青年基金获得者,973首席科学家,CMB杰出教授及吴杨奖获得者。

目前为中华医学会风湿病学分会名誉主委,国际风湿病联盟(ILAR)前主席和亚太风湿病联盟(APLAR) 前主席,中国免疫学会临床免疫分会主任委员,《Clinical Rheumatology》,《Seminars Arthritis Rheum》和《IJRD》副主编,《中华风湿病学杂志》总编,《中华临床免疫与风湿病》总编,《北京大学学报》(医学版)副主编,《医学参考报•风湿免疫频道》主编,《Ann Rheum Dis》、《Lancet Rheumatology》及《Nat Rev Rheum》等杂志编委。

长期从事风湿免疫病临床诊治,主要研究方向为类风湿关节炎、系统性红斑狼、干燥综合征等免疫性疾病的发病机制及免疫治疗。发表论文近600 篇,其中在《Nature Medicine》、《Immunity》、《Science》、《Cell H&M》、《Lancet Rheum》、《Nat Commun》等杂志发表SCI论文260余篇。主编(译)《类风湿关节炎》、《风湿免疫学高级教程》、《凯利风湿病学》等风湿病学专著20余部。 

代表性论文:

1.Fanlei Hu, Xiang Jiang, Chunqing Guo, Yingni Li, Shixian Chen, Wei Zhang, Yan Du, Ping Wang, Xi Zheng, Xiangyu Fang, Xin Li, Jing Song, Yang Xie, Fei Huang, Jimeng Xue, Mingxin Bai, Yuan Jia, Xu Liu, Limin Ren, Xiaoying Zhang, Jianping Guo, Hudan Pan, Yin Su, Huanfa Yi, Hua Ye, Daming Zuo, Juan Li, Huaxiang Wu, Yongfu Wang, Ru Li, Liang Liu, Xiang-Yang Wang and Zhanguo Li. Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study. Nat Commun. 2020;11(1):1911. 2020 Apr 20. doi:10.1038/ s41467-020-15700-3

2.Xiangjun Chen, Xiaolin Sun#, Wei Yang#, Bing Yang#, Xiaozhen Zhao, Shuting Chen1, Lili He, Hui Chen, Changmei Yang, Le Xiao, Zai Chang, Jianping Guo, Jing He, Fuping Zhang, Fang Zheng, Zhibin Hu, Zhiyong Yang, Jizhong Lou, Wenjie Zheng, Hai Qi, Chenqi Xu, Hong Zhang, Hongying Shan, Xu-jie Zhou, Qingwen Wang, Yi Shi, Luhua Lai, Zhanguo Li *, Wanli Liu* . An autoimmune disease variant of IgG1 modulates B-cell activation and differentiation. Science. 2018, 362:700-705.

3.Jing He, Xia Zhang, Yunbo Wei, Xiaolin Sun, Yaping Chen, Yuebo Jin, Xin Hu, RulinJia, ChuanhuiXu, ZhaohuaHou, Lei Zhu, JinhongFeng, Yuan An, Yuan Jia, Chun Li, Xu Liu, Hua Ye, LiminRen,Ru Li, Haihong Yao, Yuhui Li, Shi Chen,Xuewu Zhang, Yin Su, JianpingGuo, Nan Shen, Eric F. Morand, Di Yu and Zhanguo Li. Low-dose interleukin-2 treatment modulates CD4+ T cell subsets selectively in patients with systemic lupus erythematosus. Nature Medicine. 2016;22(9):991-3 

4.Liu Y, Mu R, Gao YP, Dong J, Zhu L, Ma Y, Li YH, Zhang HQ, Han D, Zhang Y, McInnes IB, Zhang J, Shen B, Yang G, Li ZG.A Cytomegalovirus Peptide-Specific Antibody Alters Natural Killer Cell Homeostasis and Is Shared in Several Autoimmune Diseases. Cell Host Microbe. 2016;19(3):400-8.

5.Zhan-guo Li. A new look at rheumatology in China - opportunities and challenges. Nat Rev Rheum, 2015;11 (5):313-317

6.He J, Tsai LM, Leong YA, Hu X, Ma CS, Chevalier N, Sun X, Vandenberg K, Rockman S, Ding Y, Zhu L, Wei W, Wang C, Karnowski A, Belz GT, Ghali JR, Cook MC, Riminton DS, Veillette A, Schwartzberg PL, Mackay F, Brink R, Tangye SG, Vinuesa CG, Mackay CR, Li Z﹡, Yu D﹡. Circulating precursor CCR7(lo)PD-1(hi) CXCR5+ CD4+ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. Immunity, 2013; 39(4):770-81.

7.Liling Xu, Mengdie Xia, Jun Guo, Xiaolin Sun, Hua Li, Chenguang Xu, Xiaomei Gu, Haowen Zhang, Junyang Yi, Yan Fang, Hengyi Xie, Jing Wang, Zhixun Shen, Boxin Xue, Yujie Sun, Tobias Meckel, Ying Hua Chen, Zhibin Hu, Zhanguo Li, Chenqi Xu, Haipeng Gong, and Wanli Liu. Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupusassociated polymorphism FcγRIIB-T232s. J Exp Med. 2016; 213:2707-2727.

8.HU F,Mu R,Zhu J,Shao WW,Shi LJ,Philip L. Cohen,Qiu XY,Li ZG. Hypoxia and hypoxia-inducible factor-1α provoke toll-like receptor signalling-induced inflammation in rheumatoid arthritis. Ann Rheum Dis 2014;73:928-936. 

9.Wang, T., X. Sun, J. Zhao, J. Zhang, H. Zhu, C. Li, N. Gao, Y. Jia, D. Xu, F. P. Huang, N. Li, L. Lu, and Z. G. Li. Regulatory T cells in rheumatoid arthritis showed increased plasticity toward Th17 but retained suppressive function in peripheral blood. Ann Rheum Dis. 2015;74 (6):1293-1301

10.Du, Y., Y. Cui, X. Liu, F. Hu, Y. Yang, X. Wu, X. Ma, X. Zuo, Y. Sheng, J. Xu, P. Zhu, L. Sun, N. Hong, X. Zhang, J. Guo, and Z. Li. Contribution of functional LILRA3, but not nonfunctional LILRA3, to sex bias in susceptibility and severity of anti-citrullinated protein antibody-positive rheumatoid arthritis. Arthritis Rheumatol.2014; 66:822-830. 

11.Joel Kremer, Zhan-Guo Li, Stephen Hall, Roy Fleischmann, Mark Genovese, Emilio Martin-Mola, John D. Isaacs, David Gruben, Gene Wallenstein, Sriram Krishnaswami, Samuel H. Zwillich, Tamas Koncz, Richard Riese, John Bradley. Tofacitinib in Combination With Nonbiologic Disease-Modifying Antirheumatic Drugs in Patients With Active Rheumatoid Arthritis. Ann Intern Med. 2013;159:253-261